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 Active
Ingredients
The active ingredients of
Revivogen® are
natural compounds proven to
inhibit 5-Alpha-Reductase
(the enzyme that produces
DHT), block the androgen
receptors and stimulate hair
growth. These active
ingredients include Gamma
Linolenic acid (GLA), Alpha
Linolenic acid (ALA),
Linoleic Acid, Oleic Acid,
Azaleic acid, Vitamin B6,
Zinc, Saw Palmetto Extract,
Beta-Sitosterol and
Procyanidin Oligomers.
Revivogen® is
the only product that
contains these ingredients
in one easy to use topical
formula..
GLA,
ALA, Linoleic Acid and
Oleic Acid
Gamma Linolenic Acid (GLA),
Alpha Linolenic Acid (ALA),
Linoleic and Oleic Acid are
essential fatty acids found
in plant oils. These fatty
acids have been individually
proven to inhibit 5-Alpha
Reductase. In fact these are
the most powerful inhibitors
of 5-Alpha Reductase known
today and not only they
inhibit the Type II form of
the 5-Alpha Reductase which
other products like Propecia®
inhibit, but also the Type I
form of the enzyme which is
present in high
concentrations in the scalp,
sebaceous glands, and the
skin. Additionally GLA, ALA
and Oleic acid have potent
anti-inflammatory
properties. Publications
Azelaic
Acid, Vitamin B6 and Zinc
Azelaic acid is a naturally
occurring dicarboxylic acid
found in whole grain
cereals, rye, and barley and
animal products. It is FDA
approved as a topical
preparation for treatment of
acne and is effective
against a number of other
skin conditions when applied
topically. There is strong
scientific evidence that
Azelaic Acid and Zinc are
potent inhibitors of
5-Alpha-Reductase. When
Azelaic acid, Vitamin B6 and
Zinc Sulfate where added
together at very low
concentrations, 90%
inhibition of 5
Alpha-Reductase activity was
obtained. The synergistic
activity of these compounds
against 5-Alpha-Reductase
makes this combination very
effective in treatment of
male pattern baldness.
By combining GLA, ALA,
Linoleic Acid, Azelaic acid,
Vitamin B6, Zinc Sulfate and
Saw Palmetto extract, we
have created a natural yet
extremely powerful anti-DHT
formula. These ingredients
work through different
mechanisms to
synergistically inhibit both
type 1 and 2 forms of
5-Alpha Reductase and
decrease DHT locally. By
decreasing the DHT levels,
hair follicles can grow and
thicken naturally, leading
to a fuller, healthier scalp
without the side effects
associated with synthetic
drugs. Publications
 Saw
Palmetto Extract
Saw palmetto has been
extensively studied over the
past several years for the
treatment of enlarged
prostate in men ( BPH ). Saw
Palmetto extract which is a
known anti-androgen is the
liposerolic extract of the
fruit of Saw Palmetto.
Saw Palmetto has shown to
effectively block the
formation of DHT and is also
believed to block the
androgen receptors which are
found on the hair follicles.
Like GLA and ALA it also
blocks Type 1 and Type 2
forms of 5 alpha-reductase
and has shown to be more
potent than Finasteride, the
active ingredient of
Propecia. Publications
Procyanidin
Oligomers
Procyanidin Oligomers
(also known as
Proanthocyanidin) are
naturally derived
ingredients that have shown
to stimulate hair growth
similarly to Minoxidil
(Rogaine®).
Recent studies by Japanese
scientists have shown that
Procyanidin Oligomers
possess growth stimulation
activity toward hair
epithelial cells in vitro
and stimulate anagen
induction in hair follicles
in vivo. Addition of
Procyanidin Oligomers to
Revivogen is intended to
increase the hair growth
stimulation properties of
the formula Publications
Publications
 Gamma
Linolenic Acid, Alpha
Linolenic Acid, and Linoleic
Acid
In the following
studies, Gamma Linolenic
Acid (GLA), Alpha Linolenic
Acid (ALA), and Linoleic
Acid were shown to be the
most potent known inhibitors
of type 1 and 2 forms of
5-alpha reductase and highly
effective in decreasing the
levels of
dihydrotestosterone (DHT),
when applied topically. More
importantly this is
accomplished without
affecting any systemic
effects.
The study further suggests
that these fatty acids can
be useful in the treatment
of disorders related to
dihydrotestosterone
including male pattern
baldness, acne, and
excessive female body hair (hirsuitism).
STUDY A: Growth
suppression of hamster flank
organs by topical
application of
gamma-linolenic and other
fatty acid inhibitors of 5
alpha-reductase.
STUDY B: Androgen
action: molecular mechanism
and medical application.
STUDY C: Inhibition
of steroid 5 alpha-reductase
by specific aliphatic
unsaturated fatty acids.
Azelaic
Acid, Vitamin B6 and Zinc
Sulfate
This article published in
British Journal of
Dermatology demonstrated
that when Azelaic acid, Zinc
Sulfate and Vitamin B6 where
combined at very low
concentrations, a 90%
inhibition of 5-Alpha
Reductase was achieved.
STUDY A: Inhibition
of 5alpha-reductase activity
in human skin by zinc and
Azelaic acid.
Saw
Palmetto
In the following studies Saw
Palmetto extract was shown
to inhibit both type 1 and 2
forms of 5 alpha-reductase (Finasteride
or Propecia®
only inhibits type
2), was more potent than
Finasteride and was able to
effectively reduce binding
of Testosterone and DHT to
their receptors on various
tissues. Please note that in
the following studies Saw
Palmetto Extract is referred
to as Permixon or lipido-sterol
extract of Serenoa repens (LSESr)
STUDY A: Human
prostatic steroid 5
alpha-reductase isoforms--a
comparative study of
selective inhibitors.
STUDY B: Testosterone
metabolism in primary
cultures of human prostate
epithelial cells and
fibroblasts.
STUDY C: The
effect of Permixon on
androgen receptors.
Procyanidin
Oligomers
In the following
studies Procyanidin
Oligomers have shown to
activate hair follicle
growth.
STUDY
A: Procyanidin
Oligomers selectively and
intensively promote
proliferation of mouse hair
epithelial cells in vitro
and activate hair follicle
growth in vivo.
STUDY
B: Proanthocyanidins
from grape seeds promote
proliferation of mouse hair
follicle cells in vitro and
convert hair cycle in vivo.
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